Dynamic organizing principals of the plasma membrane that regulate signal transduction: commemorating the fortieth anniversary of Singer and Nicolsons fluid-mosaic model. Kusumi A, Fujiwara TK, Chadda R, Xie M, Tsunoyama TA, Kalay Z, et al. Hierarchical mesoscale domain organization of the plasma membrane. Kusumi A, Suzuki KG, Kasai RS, Ritchie K, Fujiwara TK. Is the fluid-mosaic model of biological membranes fully relevant? Studies on lipid organization in model and biological membranes. Dynamic, yet structured: The cell membrane three decades after the Singer-Nicolson model. Verbe G, Szöllosi J, Matkó J, Nagy P, Farkas T, Vigh L, et al. Revisiting the fluid mosaic model of membranes. Protein lateral mobility as a reflection of membrane microstructure. An outlook on the organization of lipids in membranes: searching for a realistic connection with the organization of biological membranes. Bagatolli LA, Ipsen JH, Simonsen AC, Mouritsen OG. A century of thinking about cell membranes. Membrane structure: some general principals. Transcending the impenetrable: how proteins come to terms with membranes. The structure and insertion of integral proteins in membranes. In: Structure and Function of Biological Membranes (Rothfield LI, Ed.), Academic Press, New York, 1971, pp. 1971 The molecular organization of membranes. Lipids on the frontier: a quarter century of cell-membrane bilayers. (Poste G, Nicolson GL, Eds.), Elsevier, New York, 1977, pp. In: The dynamics of cell membrane organization. Dynamic Aspects of Cell Surface Organization. The FluidMosaic Model of Membrane Structure: still relevant to understanding the structure, function and dynamics of biological membranes after more than 40 years. Cytoplasmic influence over cell surface surface components. Transmembrane control of the receptors on normal and tumor cells. Formation of membranes by repeating units. Green DE, Allmann DW, Bachmann E, Baum H, Kopaczyk K, Korman EF, et al. On the orientation of lipids in chloroplast and cell membranes. Covalently bound ferritin as a membrane marker. The molecular structure and contact relationships of cell membranes. On bimolecular layers of lipoids on the chyromocytes of the blood. The ultrastructure of cell membranes and their derivatives. A contribution to the theory of permeability of thin films. The Fluid Mosaic Model of the structure of cell membranes. Access full text of the manuscript here: See full text (pdf) Referencesġ. These interactions are important in restraining membrane components and maintaining the unique mosaic organization of cell membranes into functional, dynamic domains. An updated Fluid-Mosaic Membrane Model is described, where more emphasis has been placed on the mosaic nature of cellular membranes where protein and lipid components are more crowded and limited in their movements in the membrane plane by lipid-lipid, protein-protein and lipid-protein interactions as well as cell-matrix, cell-cell and cytoskeletal interactions. In addition, membrane-associated cytoskeletal structures and extracellular matrix also play roles in limiting the mobility and range of motion of membrane components and add new layers of complexity and hierarchy to the original model. More recent information, however, has shown the importance of specialized membrane domains, such as lipid rafts and protein complexes, in describing the macrostructure and dynamics of biological membranes. After more than forty years the model remains relevant for describing the basic nano-scale structures of a variety of biological membranes. Email: Fluid-Mosaic Membrane Model of cell membrane structure was based on thermodynamic principals and the available data on component lateral mobility within the membrane plane. Nicolson, Ph.D, The Institute for Molecular Medicine, P.O. The Institute for Molecular Medicine, Department of Molecular Pathology, Huntington Beach, CA, USA Update of the 1972 Singer-Nicolson Fluid-Mosaic Model of Membrane Structure Discoveries 2013, Oct-Dec 1(1): e3.ĭOI: 10.15190/d.2013.3 Submitted: DecemAccepted: DecemPublished: DecemGO BACK to 2013, Oct-Dec issue Update of the 1972 Singer-Nicolson Fluid-Mosaic Model of Membrane Structure.
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